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Autor:  

Yan, Li

Titel:  

Changes in pre- and postsynaptic function during the phase of enhanced long-term synaptic plasticity at the border of focal lesions in rat visual cortex

übersetzter Titel:  

Änderungen der prä- und postsynaptischen Funktion in der Phase verstärkter synaptischer Plastizität im Randbereich von fokalen Läsionen im visuellen Kortex der Ratte


Dissertation 
URN:  urn:nbn:de:hbz:294-22067
URL:  http://www-brs.ub.ruhr-uni-bochum.de/netahtml/HSS/Diss/YanLi/diss.pdf
Format:  application/pdf (1.6 M)
Kommentar:  Ruhr-Universität Bochum, International Graduate School of Neuroscience. Tag der mündlichen Prüfung: 2008-01-14

Inhaltsverzeichnis
Datei:  http://www-brs.ub.ruhr-uni-bochum.de/netahtml/HSS/Diss/YanLi/Inhaltsverzeichnis.pdf
Format:  application/pdf (115.3 k)

Zusammenfassung
Datei:  http://www-brs.ub.ruhr-uni-bochum.de/netahtml/HSS/Diss/YanLi/Zusammenfassung.pdf
Format:  application/pdf (93.1 k)

Abstract
Datei:  http://www-brs.ub.ruhr-uni-bochum.de/netahtml/HSS/Diss/YanLi/Abstract.pdf
Format:  application/pdf (74.6 k)

Schlagworte:  Läsion; Sehrinde; Syaptische Transmission; Langzeitpotenzierung; NMDA-Rezeptor

Inhalt der Arbeit: 

Focal lesions in the visual cortex have been shown to induce enlarged receptive field sizes and an enhanced long-term potentiation (LTP). However, the synaptic mechanism of the lesion-induced facilitation of LTP is not fully understood. Therefore, the present thesis studied possible changes in pre- and postsynaptic function of neurons located at the border of lesion in rat visual cortex. This study showed an increased presynaptic glutamate release probability in lesion-treated visual cortex. The enhanced presynaptic glutamate release is mediated by activation of the presynaptic NMDARs and BDNF-TrkB receptor pathway. The lesion also affects the functional properties of postsynaptically located NMDARs containing the NR2B subunits. In addition, neurons at the border of the injury showed a decreased GABAergic inhibition. The findings of the present study indicate that a focal cortical lesion in visual cortex changes both, the pre- and postsynaptic function of neighbouring neurons.


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