The survival of most animals is directly associated with the accuracy of their olfactory system. To maintain signal specificity in the olfactory system, many mechanisms have evolved to control signal initiation, duration and termination.
Understanding the complex mechanisms underlying these modulation processes requires extensive knowledge about the various molecular components involved. Modulation of olfactory signaling in the periphery can be achieved by regulating the amplification
of the olfactory signal, the adaptation of olfactory sensory neurons or by maintaining the olfactory signaling specificity.
The present work intends to elucidate (1) the molecular identity of the olfactory calcium-activated chloride channel, (2) the internalization processes of olfactory receptors in native olfactory sensory neurons and (3) the role of the scaffolding
protein MUPP1 in the olfactory system.